This article discusses the role of translation and its impact on the success of patient education materials, particularly in the context of patient recruitment and retention for clinical trials. We examine how translation and localisation help foster trust, ensure safety, and increase efficiency, improving recruitment, retention, and regulatory compliance in trials which are becoming increasingly diverse. We also discuss inherent challenges and considerations and look into the future. Medical Writing. 2024;33(1):48–53. https://doi.org/10.56012/egqe7421