Just as the research and development of new drugs requires careful, often painstaking, adherence to empirical processes, the peer-review process and, indeed, the manuscript preparation process, are likewise laborious and time-consuming. The benefits of these are obvious and important, given how critical peer review serves as a “gatekeeper” for the disclosure of new scientific and medical information. However, we must consider weighing the potential value of rapid publication against the potential harm of inadequate vetting (both internal and external) of the final product.