Non-communicable diseases are rising at an alarming rate across the globe, with many attributed to our sedentary habits, unhealthy diets, chronic stress, poor sleep, and social, and environmental factors. Lifestyle medicine is an evidence-based discipline that has the potential to prevent, treat, and sometimes reverse chronic illnesses by addressing modifiable lifestyle factors through behavioural interventions. This article highlights the importance of real-world data to objectively evaluate outcomes and advance research in lifestyle medicine. We explore the current literature and the characteristics of the body of evidence on lifestyle interventions and provide tips for medical writers when working with this type of data.