A great deal has happened in the world of regulatory public disclosure in Europe in 2022 with the EU Clinical Trials Regulation (CTR) 536/2014 coming into force at the end of January 2022. We collectively attempt to assimilate knowledge and experience of protocols prepared for and conducted under the Regulation as a first learning step, and to appreciate the nuances of how trials registered under the CTR will be entered and displayed in the Clinical Trials Information System (CTIS). Zuo Yen Lee (editor) Clare Chang (editor)