Health technology assessment (HTA) is a relatively recent innovation that has changed the way decisions are made in healthcare. It is a multidisciplinary process that requires different skill sets and collaboration among various disciplines and agencies. Evidence in the form of systematic reviews or HTAs – and more recently, overviews of systematic reviews – is increasingly being used by decision makers in healthcare globally. Key aims are to reduce duplication of effort and to provide appropriate evidence to assist people to make evidence-informed decisions about health care. Global and regional networks have been established to collaborate on reviews and HTAs, share knowledge, and reduce duplication. However, a very real example of inefficient evidence generation for decision making has been seen with the current COVID-19 pandemic where “eminence-based decisions” (based on the opinions of prominent health professionals) led the way early on. Hopefully, lessons can be learned from this in the future.