Systems biology and real-world data as drivers of change in drug research and development In recent years, systems biology is not only being applied in fundamental science but also in drug development and healthcare. The application of real-world data in clinical research generates a large volume of data and information that is difficult to handle without a proper tool to process, decode, and interpret the data. That is where systems biology comes into play. This article discusses  the idea of applying systems biology in clinical research and how it may play an important role in facilitating the process of drug development. Contributors: Arunon Sivananthan (author), Zuo Yen Lee (section editor), Clare Chang (section editor) Medical Writing. 2023;32(1)122-125. https://doi.org/10.56012/awvf3242