The increasing amount of data available together with advances in computer science are converting computers from simple tools that execute commands into self-taught, self correcting machines that make decisions. This is the beginning of the era of artificial intelligence (AI) that promises a revolution in the way we live and work. AI has entered apace the fields of healthcare and medicine and has started to affect the work of medicalwriters. A recent survey has revealed that 40% of scientists are still unfamiliar with the use of AI in healthcare with opinions ranging from panic to over-optimism. These are big challenges for all medical writers (MWs). This article discusses the critical role MWs play in an AI-driven healthcare, describes how AI can empower medical writers in various domains (regulatory, medical affairs, redaction, and publishing), and highlights the importance of staying up-to-date with the AI world.