When it comes to remote working, we often think about the many benefits this approach brings, such as being more flexible and productive, or improving our work-life balance. However, remote working without the right framework to profit from all these benefits can leave us feeling fatigued, isolated, or even depressed. I experienced the pros and cons of remote working both as an employee and a freelancer and searched for preventive strategies to improve wellbeing and preserve mental health. Medical Writing. 2022;31(3)32-34. https://doi.org/10.56012/psmk8028